The current Medicat download is designed to make a Ventoy USB drive and you can just extract the contents of the large MediCat.USB.v21.12.7z onto your E2B USB drive and use 'Ventoy for Easy2Boot' to boot the files or agFM menu system.
However, if you want to use the payloads with the E2B menu system then you will need to extract each of the .iso and .wim files from the .7z package and individually copy them to the E2B menu folders (or use a .cmd script - see below).